Classification of fires. The trick, of course, is managing your time efficiently. Knowledge of the vendor selection process. A system of an overall assessment and management of excipient risks is incorporated in the pharmaceutical quality system of a finished medicine manufacturer. Inflammable Gasses Process safety in the pharmaceutical industry | BEKO TECHNOLOGIES Discussed here are the tips to maintain improved health and safety standards in the pharmaceutical industry. Risk assessments aim to scale the level of risk present to determine if any event or substance needs to be altered or eliminated. Having optimal practices in place and ensuring that all employees adhere to them can help improve health and safety standards in the workplace. With more than 1,300 locally owned and operated stores from coast to coast, the . From the production of active pharmaceutical ingredients (APIs) to the formulation of finished drugs, high-pressure vessels play a crucial role in the pharmaceutical industry. 0000004983 00000 n Whats unique to the pharma industry is that employees are routinely exposed to chemicals in the workplace as part of their job. Process Safety Technical Areas Dust Hazards Most solid materials that can be ignited can form an explosive dust cloud if the particle size of the solid is small enough. Limited access to a hazard or eliminating the hazard altogether is one of the best ways to take action. 0000001306 00000 n While there is a continuing demand for a single volume, many managers and safety practitioners enter the field of safety with some qualifications already gained in an earlier part of their career. for(var i = 0; i < country_list.length; i++) { [PPT] Industrial Hazards And Safety Measures - Pharmawiki.in 0000006885 00000 n Satara College of Pharmacy, Satara. International Journal of Engineering Trends and Technology, (IJETT), Understanding the health and hazards of the Laboratory Assistants in Pharmacy Colleges in Mumbai, A Member of the International Code Familyn > & '- INTERNATIONA, LESSON 1 Introduction to fire protection set-ups, Review on Industrial Hazards and its Prevention, ENVIRONMENTAL IMPACT ASSESSMENT FOR RISK ASSESSMENT AND MANAGEMENT PLAN OF CEMENT, Fire Code IRR of RA 9514 (Fire Code of the Phils), By Authority Of THE UNITED STATES OF AMERICA Legally Binding Document, RA9514_NATL FIRE CODE OF THE PHILIPPINES - Copy.pdf, RA9514_NATL FIRE CODE OF THE PHILIPPINES.pdf, Hazard identification, Risk assessment & consequence modelling of pool fire of bulk stored crude in tank Farm, -09 IRR of RA 9514 (08 Fire Code of the Phils), Safety in academic chemistry laboratories faculty, Fire Safety Management Handbook Third Edition By Daniel E Della Giustina-watermark.pdf, Fire Code of the Philippines 2008 IRR RA9514, Fire Safety Management Handbook Third Edition, Fire protection facilities for terminals, pipelines Std-, Fire Safety Preparedness in Building Construction Sites in Dar-Es-Salaam, Tanzania, INDUSTRIAL FIRE PROTECTION HANDBOOK Second Edition. 0000003669 00000 n Ivana Zeli - Medical Sales Representative - Sandoz | LinkedIn Int. are important to protect the people from their consequences. WHAT DOES INDUSTRIAL HAZARD MEANT? High temperature, high pressure or oxidation often causes chemicals to explode or release. 0000089879 00000 n From prescriptions to walk-in clinics, and a beloved loyalty program, we're caring and supporting our customers in new ways every day. Some of the OSHA recommended measures for risk assessment include: The many hazardous chemicals that pharmaceutical companies work with need to be handled carefully. Safety equipment such as an emergency safety shower or an eyewash station is another must-have safety consideration. 0000003386 00000 n It is mandatory to procure user consent prior to running these cookies on your website. Pharmaceutical Manufacturing Safety Considerations, cGMP Temperature-Controlled Stability Studies, cGMP Synthesis, Purification, and Analysis of Tritium-labeled APIs, Custom GLP Synthesis of Radiolabeled Compounds, Custom Synthesis of Radiolabeled Compounds, Oligonucleotide Custom Synthesis with Carbon 14 or Tritium, Radiochemical Purity Determination by HPLC, Liquid Chromatography-Mass Spectrometry Analytical Services, Liquid Chromatography / Mass Spectrometry (LC/MS), Comprehensive Logistics Services for Laboratories, Custom GLP Synthesis of Stable Labeled Compounds, Custom Synthesis of Stable Labeled Compounds, Custom Synthesis Services for Non-Labeled Compounds, Nuclear Magnetic Resonance (NMR) Analytical Service, The Purpose of Preliminary Testing for New Drugs, Wear eye protection and other personal protective equipment (PPE), Do not wear clothing that exposes the skin (eg, shorts and T-shirts), Regularly check that glassware is not cracked and that all equipment is safe to use. The control and prevention of contamination is integral in the pharmaceutical industry to ensure safety and quality of products The We are one of Europes leading textile service companies with over 170 years of experience in the textile industry. lling and making aseptic connections. In addition to the common safety hazards found across industries, the pharma companies also have some unique hazards that necessitate continuous monitoring and improvement of safety processes all the way to the patient and subsequent feedback. Deviation & Change Control in Pharma - MasterControl Based on OSHA guidelines, the following key steps can be taken to maintain health and safety at the laboratory: For any pharmaceutical company, employees are the biggest asset. 21 Free Pharmaceutical PowerPoint Templates and Icon Packs - 24Slides It also makes it easy to digitally transform audit and supplier management workflows and processes across the value chain. Pharma companies committed to the environment and employee health and safety will benefit by implementing the following five best practices: The laboratory is one of the key work areas in a pharma company that also has high risks due to the usage of chemicals and pathogens in testing and development. Tips to Practice Health and Safety in the Pharma Industry - EHS Insight The system also highlights how to properly store, label, and move chemicals to minimize the risk of a dangerous event such as a fire occurring. We also use third-party cookies that help us analyze and understand how you use this website. This is an exciting opportunity for an Associate Process Chemist to join a leading agricultural sciences company. jQuery('#demovideo-country').append(options); To learn more about contamination control in the pharmaceutical industry, download the below eGuide. The Occupational Safety and Health Administration (OSHA) provides extensive guidelines regarding lab safety, but there are a few basic steps that any employer or worker can keep in mind. From identifying/analyzing risks to establishing safety protocols, documenting processes, training employees, and automated incident management, the solution provides a comprehensive safety management solution. We offer comprehensive EHS software solutions for biotech and pharma companies just like you. The constant evolution of regulatory standards to ensure safe workplaces has also played a significant role in improving EHS processes. V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= Next, note who may be at risk as a result of any dangers identified in step one. Therefore, it is important to have optimal health and safety practices while ensuring that all employees adhere to such regulations. Figuring out health and safety in the pharma industry can often feel like an uphill battle. Regularly check that all equipment is working properly and safe to use, Wear head cap to prevent contamination through hair, Visibly demonstrate and inspire through your commitment to inculcate an injury and incident free culture, Educate employees that they are accountable for their own safety and also for the safety of those around them, Implement effective management that helps identify, control and eliminate all types of hazards up to an acceptable limit, Take appropriate action to prevent the reoccurrence of incidents and injuries through effective investigation and anticipatory strategy development, Implement and regulate corporate safety standards across all your pharmaceutical buildings, offices and laboratories, Conduct injury-free survey wherever appropriate to discover opportunities for improvements. It appears that you have an ad-blocker running. Effective risk evaluation is the cornerstone of assessing the potential hazards at workplace and ensuring safety of the employees. T8UB/&GaxO~u5|no'D*CSd0,ak-Fc4$`"D^@'#`K K.2]cX?u7X-J]/V^7[){m"*\maj*=TmEa7b{SdPvv,M1/uy'?EDiDk^u6=,1F #y2G]>4cS8U3 Mr$B%%q#o` K This Pharma Health template is a packed graphic presentation and ideal for pharmaceutical representatives, pharmacologists, and pharmacy technicians. Maintaining Health and Safety in the Pharmaceutical Industry A cloud-based solution built on the Salesforce platform- CQ EHS provides end-to-end visibility into safety processes across the organization by seamlessly integrating with other enterprise software such as ERP, CRM, eQMS, PLM, and so on. Although there are some examples of the use of quality risk SAFETY V>tRl4)?NdCsA>C'$m{m),e`Z5O GYQOYEl]"ZU{mk@Y@_0n.cC/5\,yCQq[v>P.4pdb[34z8ZXXc?.V@oa8-gEyMSDEd3-kYvZl4\jt0E+ATa$VxI#y1S06.xCd8{%C'7O# kiWEk0nL|w(rrg*TM$y)\{7"|cMD] rVJ$ bH4! Rev. | Learn more about Ivana Zeli's work experience . Sorry, preview is currently unavailable. Know the most toxic environmental hazardous substances PDF Some observations about major chemical accidents from recent CSB Pankaj Sinha - Life Sciences - Digital Plant Architect - MilliporeSigma Revenues by similar products. According to IBIS World, the pharmaceutical industry generated ~$1260 trillion in revenue in 2019. the Occupational Safety & Health Administration are examples of industrial safety policies. Practice school session on "GOOD Documentation Practices" dated 08.01.2021 by Regulatory requirements for drug approval. Download Free Pharmaceutical PowerPoint Presentations We invite you to download the free Pharmaceutical PowerPoint presentations under this section. Author: Hughes Safety Showers Learn faster and smarter from top experts, Download to take your learnings offline and on the go. Despite the crisis significantly affecting the supply chain, the pharma Hygiene and cleanliness are mandatory practices that every pharmaceutical manufacturing facility must implement and regulate. 0000002220 00000 n Always request a safety data sheet if it is not given and keep them easily accessible to pharmaceutical manufacturing employees at the appropriate workstation. It appears that you have an ad-blocker running. Impurities or oil contaminations in medicaments through compressed air can quickly have fatal consequences. major health and safety hazards encountered in the operations of chemical and Listed on 2023-03-03. Generally, process validation is done before releasing a new product, when applying any . Safety methods in pharmaceutical industry - SlideShare [PPT] Industrial Hazards Due To Fire And Mechanical Equipment f SAFETY ASPECTS IN PHARMACEUTICAL HAZARDS Personal protective equipment for hazardous drug handling Disposable gowns made of fabric that has low permeability to the agents in use, with closed fonts and cuffs,intended for single use. Pfizer Canada is looking to hire a talented summer student with proficiencies in online data research and project management. Title: Process Safety Management Author: Steve Davis User Last modified by: Linda Vosburgh Created Date: From scientific and medical development to more business-focused templates, this pack will give you a complete set of useful PowerPoint resources. Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. Consistently relying on basic laboratory safety precautions, performing risk assessments, keeping material safety data sheets, providing further documentation, and properly handling chemicals is the best way to maintain pharmaceutical manufacturing safety measures. If a problem is found, there should be steps taken to remedy the issue immediately. We work with 75 of the Fortune 500 companies and work on 2,000 new job requisitions per month. HUn@s\?RUCcCcwv&Hu"X3!_\ ?I&!4U_lwoE\a^?gTqco!eL {lGyy;O`d4K=n@ Qr[]e)PfFrW]B=p9wKA%Ls %<60T%E% fV\en4,7r8%P0"L}eQJv*NRY]m{m4k[]i*~Y/Sr|\(Nt':.R"o1~9;vK$?$q!JGad(4 Consider installing eye wash stations inside the facility to minimise the risk of major damages. PPT Slide 1 Template For Professional Presentation Pharmaceutical Industry Patent Expiration. The Occupational Safety and Health Administration (OSHA) have comprehensive guidelines regarding how to practice lab safety. 0000002462 00000 n Initial Performance Qualification - This sampling allows pharmaceutical manufacturers to verify the system is clean, ensuring that no contaminants are present before beginning production. cy\H'0IfifSe VxIgMC# mRYxND 6IcCF` 1 endstream endobj 236 0 obj 1153 endobj 214 0 obj << /Type /Page /Parent 202 0 R /Resources 215 0 R /Contents 221 0 R /MediaBox [ 0 0 612 792 ] /CropBox [ 0 0 612 792 ] /Rotate 0 >> endobj 215 0 obj << /ProcSet [ /PDF /Text ] /Font << /TT2 216 0 R /TT4 217 0 R /TT6 223 0 R /TT8 224 0 R /TT10 225 0 R >> /ExtGState << /GS1 230 0 R >> /ColorSpace << /Cs6 220 0 R >> >> endobj 216 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 241 /Widths [ 250 333 408 500 500 833 778 180 333 333 500 0 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 0 564 0 444 0 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 611 333 0 333 0 500 0 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 0 0 0 541 0 0 0 0 0 0 1000 0 0 0 0 0 0 0 0 0 0 0 333 333 444 444 0 500 1000 0 0 0 0 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 722 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 722 0 0 0 0 0 0 0 0 0 0 444 0 0 0 0 0 0 0 444 0 0 0 278 0 0 0 500 ] /Encoding /WinAnsiEncoding /BaseFont /JEAHCO+TimesNewRoman /FontDescriptor 219 0 R >> endobj 217 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 32 /Widths [ 352 ] /Encoding /WinAnsiEncoding /BaseFont /JEAHEA+Verdana /FontDescriptor 218 0 R >> endobj 218 0 obj << /Type /FontDescriptor /Ascent 1005 /CapHeight 0 /Descent -209 /Flags 32 /FontBBox [ -50 -207 1447 1000 ] /FontName /JEAHEA+Verdana /ItalicAngle 0 /StemV 0 /FontFile2 231 0 R >> endobj 219 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -568 -307 2000 1007 ] /FontName /JEAHCO+TimesNewRoman /ItalicAngle 0 /StemV 94 /XHeight 0 /FontFile2 229 0 R >> endobj 220 0 obj [ /ICCBased 228 0 R ] endobj 221 0 obj << /Length 858 /Filter /FlateDecode >> stream v%m1K[Z: f+v;BV+va eB`KBO{_/|?y}| F NbImHOt(SH0?Re?>C gtG d;]}W4v9$wx!P(2AG rm>I|=@OmzzmE{zbPBOi;=FJ.]j&RXW/p_ktX,L sM8*E,9.@6z(oxq9N?_zY`>m1 bS;qMt& Potential cause for a fire. While PPE should be the frontline method of protection, these are tools that can be used to clean any chemicals off the eyes, skin, or clothing to minimize long-term damage from coming in contact with unsafe materials in case a hazardous event occurs. N')].uJr x- [ 0}y)7ta>jT7@t`q2&6ZL?_yxg)zLU*uSkSeO4?c. R -25 S>Vd`rn~Y&+`;A4 A9 =-tl`;~p Gp| [`L` "AYA+Cb(R, *T2B- Typically, the following steps are involved in health and safety risk assessment: In the pharmaceutical industry, maintaining basic safety in the laboratory is mandatory. Mechanical hazards 3+ years' work experience working in a project management capacity in the pharmaceutical or biotech industry, managing budgets and timelines. The SlideShare family just got bigger. By accepting, you agree to the updated privacy policy. SIGNIFICANCE OF PHARMACEUTICAL REGULATORY BODIES - A REVIEW - PharmaTutor The documents can also be used as a reference when hazards do arise to determine where in the process changes need to be made. A({RPgq:U{_9*%$o.J)5Lr=Vn6%lnbr% M. tech (Indu. Department of Pharmacy "F$H:R!zFQd?r9\A&GrQhE]a4zBgE#H *B=0HIpp0MxJ$D1D, VKYdE"EI2EBGt4MzNr!YK ?%_&#(0J:EAiQ(()WT6U@P+!~mDe!hh/']B/?a0nhF!X8kc&5S6lIa2cKMA!E#dV(kel }}Cq9 V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= OSHAs detailed guidelines on laboratory safety include: A risk-based approach helps pharma companies identify potential incidents and analyze their impact on employees, products, and the environment. SAFETY METHODS IN PHARMACEUTICAL INDUSTRY ssuser5a17b2 1.1k views 16 slides Industrial hazards and safety Naresh Gorantla 678 views 41 slides Pharmaceutical industrial safety Namdeo Shinde 63.3k views 117 slides Industrial hazards and plant safety Md. 0000002378 00000 n Documentation of the entire production workflow is essential to ensure that the employees follow it diligently and avoid unsafe protocol. If you need somewhere to get started, try these steps to conduct an assessment: In the long term, you should also do an annual review of assessments. 2021 Challenges and Trends in Pharmaceutical Industry HyTSwoc [5laQIBHADED2mtFOE.c}088GNg9w '0 Jb Prasad, APPCB Environment Engineer P. Prasada Rao, and A. Ramalingeswara Raju of the. Our team is looking for a proactive, energetic student that has completed at least the 1st year of University and is interested in working with a dynamic team to gain commercial experience in the pharmaceutical industry. 0 25-Aug-15 1SATARA COLLEGE OF PHARMACY, SATARA. They are looking for insight and evidence around the safety, clinical and cost-effectiveness of health care delivery systems, medical devices, and . This review provides technical information regarding hazards in the pharmaceutical sector and our aim is to bring awareness about hazards, avoidance of hazards, be in preparedness mode to suitably respond to the effects and impacts of hazards including Disaster Management in the pharmaceutical industry. Free Pharmaceutical PowerPoint Presentations | MedicPresents.com This will also ensure traceability and visibility, leading to continuous improvement. We help our customers of all sizes deliver quality products and services in the safest, most sustainable way by mitigating risk, problems, and inefficiencies while protecting customers, employees, suppliers and brand. From within the pharmaceutical industry, I have a keen grasp for regulations, procedures, safety and compliance, and understand the significance of the decisions I make. In this environment, change control describes the process of managing how . Explore more workplace safety resources from the EHS Insight Blog. However, change typically refers to an intended move to a new validated state, whereas deviation is an unintended change from the validated state. Their need is to add to their store of knowledge specific information in a particular sector. Some of the key steps here are: D. Health & Safety Standards in Handling Chemicals. Local manufacturers account for a paltry 10 percent of the medicine supply needs of the country. accidents (West pharmaceutical) occurred at a manufacturer of rubber stoppers and similar products for medical devices and pharmaceuticals. In this blog, we'll explore the use of high-pressure vessels in the . These cookies do not store any personal information. Thats where we can help. Activate your 30 day free trialto unlock unlimited reading. Necessary cookies are absolutely essential for the website to function properly. PDF Hazardous Area Classification in Pharmaceutical Industry - IJERT Tips to Practice Health and Safety in the Pharma Industry. The pharmaceutical industry has been described as dynamic and growing, in terms of sales, number of employees and GDP. 3+ years' experience with pharmaceutical/biologics manufacturing and quality management systems. nQt}MA0alSx k&^>0|>_',G! Maintaining safety can be difficult forpharmaceutical manufacturing companies. 9-mth ended Sept. 26, 2004. WHAT IS INDUSTRIAL SAFETY? Online/Remote - Candidates ideally in. In other industries, this may seem excessive. 0000003570 00000 n wG xR^[ochg`>b$*~ :Eb~,m,-,Y*6X[F=3Y~d tizf6~`{v.Ng#{}}jc1X6fm;'_9 r:8q:O:8uJqnv=MmR 4 The good news is that this is relatively straightforward if you abide by regulatory guidelines and use the right tools to stay on track. Those expenditures covered a variety of activities, including discovering and testing new drugs, developing incremental innovations such as product extensions, and clinical testing for safety-monitoring or marketing purposes. Here are a few other suggested pharmaceutical manufacturing safety considerations. The sector has five broad areas of Free Pharmaceutical PowerPoint Templates 8: Genetize & Free World Cancer Day jQuery(document).ready(function(){ 0000112054 00000 n Dust hazards 0000001996 00000 n Personal Protective Equipment (PPE) such as gloves and eye protection should always be worn. Listing for: Alector, Inc. Remote/Work from Home position. N')].uJr Experienced Medical Sales Representative with a demonstrated history of working in the pharmaceuticals industry. We've encountered a problem, please try again. Personnel directly involved with the manufacturing and handling of pharmaceutical products are constantly exposed to chemical and biological hazards. Legally, the risk must either be removed or minimized. <<2B8B34741856CE4EB805EE87661CC449>]>> Free Pharmaceutical PowerPoint Templates for Medics - Blog RRGraph Design console.log(country_list); The pharmaceutical manufacturing industry presents unique risks to employees due to the increased likelihood of interacting with hazardous chemicals. With the combination of risk assessments and other precautionary measures like outlining PPE requirements, a detailed description of the manufacturing process can include specific instructions for avoiding unsafe protocol. Fire. Powder free gloves, labeled and tested for drugs used with chemotherapy , made of latex, nitrile 0000006094 00000 n The Pharmaceutical Industry Presented to Geoffrey Poitras Bus 417 Thursday, March 16, 2006 Revenue Breakdown. However, by putting simple checks and procedures in place, even the most problematic environments can be monitored safely. professor Tareq abdhulkadhum naser Alasadi, Health and safety is not a subject in its own right but is an integration of knowledge and information from a wide spectrum of disciplines. Regulatory bodies recommend a risk-based approach to help pharma companies identify risks, prioritize them based on the severity of impact, and implement mitigative measures to minimize or eliminate the risks. As such, the best way to keep your employees safe from harm is to conduct frequent risk assessments and regular checks to ensure that safety standards are being followed. Industrial hazards in pharmaceutical plant, Safety methods in pharmaceutical industry, SAFETY METHODS IN PHARMACEUTICAL INDUSTRY, Industrial hazards and prevention systems, Ich guidelines on risk assessment and risk mangment, Critical hazard management system hasm presentation, Waste generation in pharmaceutical manufacturing industry, A Risk Assessment Study on Occupational Hazards in Cement Industry, Chemical industry & its safety training, Ammonium Carbonate - Hazardous Substance Fact Sheet, Guidelines on-storage-of-hazardous-chemical-a-guide-for-a-safe-w, Nitrosamine Impurities; A Failure, Challenge & Threat. Officers. In the pharmaceutical industry, it is legally obligatory to conduct thorough health and safety risk estimation. Bayer submits aflibercept 8 mg for marketing authorization in Japan The previous steps should be recorded, including documenting what the risk was and what action was taken. endstream endobj 105 0 obj<> endobj 106 0 obj<> endobj 107 0 obj<>/Font<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 108 0 obj<> endobj 109 0 obj<> endobj 110 0 obj[/ICCBased 117 0 R] endobj 111 0 obj<> endobj 112 0 obj<> endobj 113 0 obj<> endobj 114 0 obj<>stream Shed lights on type of toxicity by industrial hazards Take action to decide how the problem will be addressed. 2010). Respondents reported that they have difficulties supplying drugs Design of gastroretentive bilayer floating films of propranolol hydrochloride recent advances in vesicular drug delivery system. 0000009785 00000 n Lecturer The manufacturing process involved running rubber strips through a slurry of polyethylene and water. Laboratory hazards, safety and contamination, Chemical Safety and Handling in Pharmaceutical Industries.pptx, Health, safety and environmental hazards in Agriculture Sector, Industrial Hygiene Heros in the Workplace, Public, and Environment, GPAT 2022 Preparation Strategies by Pharma Scholars Academy. Ensure all your employees are aware of the primary health and safety practices and take preventive measures when working in a hazard-prone environment. Maintaining Health & Safety Standards . First, there is the danger of employees that handle hazardous drugs such as cytotoxics that expose workers to harmful workplace environments. Sign up for the latest news on environmental, health, and safety. Chart1. Pharmaceutical PPE and Safety Protocols for Your Company Aflibercept 8 mg has been shown to be highly durable, with comparable visual acuity and safety to the gold standard, Eylea. Free access to premium services like Tuneln, Mubi and more. These cookies will be stored in your browser only with your consent. Make sure to check for any particular dangers to be aware of, as outlined by OSHA. Risk assessments work to identify and analyze any potential events or substances that may negatively impact individuals, products, or the surrounding environment. 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